| mir-218 microRNA precursor family | |
|---|---|
| Predicted secondary structure and sequence conservation of mir-218 | |
| Identifiers | |
| Symbol | mir-218 |
| Rfam | RF00255 |
| miRBase | MI0000294 |
| miRBase family | MIPF0000026 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding.
miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species.[1] The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin.
miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma.[2] It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth.[3] miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.[4]
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